期刊
DIABETES CARE
卷 31, 期 2, 页码 361-362出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc07-1276
关键词
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资金
- Erasmus Medical Center
- Erasmus University Rotterdam
- Netherlands Organization for Scientific Research
- Netherlands Organization for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly
- Ministry of Education, Culture and Science
- Ministry of Health, Welfare and Sports
- European Commission
- Municipality of Rotterdam
- Hormozgan University of Medical Science, Bandar Abbas, Iran
OBJECTIVE - To investigate the association between serum uric acid level and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS - The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes. RESULTS - The age- and sex-adjusted hazard ratios (HRs) (95% Cls) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively. CONCLUSIONS - The results of this population-based study suggest that Serum uric acid is a Strong and independent risk factor for diabetes.
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