期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 283, 期 5, 页码 2784-2792出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M703265200
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资金
- NIAID NIH HHS [AI 042310] Funding Source: Medline
- NIAMS NIH HHS [AR 049610, AR 050498] Funding Source: Medline
Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses. It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In the current study, we investigated the role of MIF in B cell survival. We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-kappa B activation, proliferation, and survival in a CD74-and CD44-dependent manner. Thus, MIF regulates the adaptive immune response by maintaining the mature B cell population.
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