期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 2, 页码 107-119出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2251
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The ability to develop and sustain populations of memory T cells after infection or immunization is a hallmark of the adaptive immune response and a basis for protective vaccination against infectious disease. Technical advances that allow direct ex vivo identification and characterization of antigen-specific CD8(+) T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8(+) T-cell generation. Here, we dissect the input signals that shape the characteristics of the memory CD8(+) T-cell response and discuss how manipulation of these signals has the potential to reshape CD8(+) T-cell memory and improve the efficacy of vaccination.
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