期刊
GENES AND NUTRITION
卷 2, 期 4, 页码 319-322出版社
SPRINGER
DOI: 10.1007/s12263-007-0067-9
关键词
caffeic acid phenethyl ester; hepatocellular carcinoma; invasion; matrix metalloproteinases; nuclear factor kappa B
资金
- Ministry of Science and Technology, Republic of Korea [2007-01866]
Numerous studies have shown that the levels of matrix metalloproteinase (MMP)-2 and/ or MMP-9 are associated with the invasive phenotypes of cancer cells. This study investigated the effects of caffeic acid phenethyl ester ( CAPE), a chemopreventive phytochemical derived from honeybee propolis, on the invasive phenotype of SK-Hep1 human hepatocellular carcinoma cells (SK-Hep1 cells). CAPE effectively suppressed SK-Hep1 cell invasion in a dose-dependent manner. The constitutive expression of MMP-2 and MMP-9 in SK-Hep1 cells was almost completely abolished by treatment with 12.5 mu M CAPE. CAPE also significantly inhibited nuclear factor kappa B (NF-kappa B) DNA-binding activity in SK-Hep1 cells. These results taken together suggest that CAPE exerts antimetastatic potential through inhibition of MMP-2 and MMP-9 expression, possibly by targeting NF-kappa B in hepatocellular carcinoma.
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