期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 2, 页码 120-130出版社
NATURE RESEARCH
DOI: 10.1038/nri2252
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- NHLBI NIH HHS [R01 HL081612-03, 1R01HL081612-01, R01 HL081612, R01 HL081612-04] Funding Source: Medline
- NIAID NIH HHS [T32 AI007328] Funding Source: Medline
- NIDDK NIH HHS [5R01DK068348] Funding Source: Medline
MicroRNAs ( miRNAs) are an abundant class of evolutionarily conserved small non-coding RNAs that are thought to control gene expression by targeting mRNAs for degradation or translational repression. Emerging evidence suggests that miRNA-mediated gene regulation represents a fundamental layer of genetic programmes at the posttranscriptional level and has diverse functional roles in animals. Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses.
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