期刊
PEDIATRIC BLOOD & CANCER
卷 50, 期 2, 页码 381-383出版社
WILEY
DOI: 10.1002/pbc.20950
关键词
acute leukemia; hemophagocytosis; infections
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK-cell lymphoid neoplasms. HLH with B-cell malignancies is less common and HLH has rarely been described in association with precursor B-cell acute lymphoblastic leukemia (B-ALL). We report three cases of HLH associated with B-ALL and review 17 cases of ALL-associated HLH previously reported in the literature. Pediatr Blood Cancer 2008;50:381 - 383. (c) 2006 Wiley-Liss, Inc.
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