期刊
GLYCOCONJUGATE JOURNAL
卷 25, 期 2, 页码 157-166出版社
SPRINGER
DOI: 10.1007/s10719-007-9068-6
关键词
saponin; synthesis; H2SO4-silica; growth-inhibitory
Simple and convergent synthesis of a tetra- and a trisaccharide portions of an antitumor compound Julibroside J(28), isolated from Albizia julibrissin, that showed significant in vitro antitumor activity against HeLa, Bel-7402 and PC-3M-1E8 cancer cell lines is reported. The tetrasaccharide has been synthesized as its p-methoxyphenyl glycoside starting from commercially available D-glucose, L-rhamnose and L-arabinose. The trisaccharide part has been synthesized from commercially available N-acetyl D-glucosamine, D-fucose and D-xylose using simple protecting group manipulations. Sulfuric acid immobilized on silica has been used successfully as a Bronsted acid catalyst for the crucial glycosylation steps.
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