期刊
JOURNAL OF VIROLOGY
卷 82, 期 4, 页码 1827-1837出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01581-07
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资金
- NCRR NIH HHS [M01 RR000051, 5M01 RR000051] Funding Source: Medline
- NIDDK NIH HHS [R01 DK060590] Funding Source: Medline
The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients with acute HCV infection. Here, we comprehensively examined total HCV-specific CD4(+) and CD8(+) T-cell responses and identified functional T-cell thresholds that predict recovery. Interestingly, we found that the presence of HCV-specific cytotoxic T lymphocytes (CTLs) that can proliferate, exhibit cytotoxicity, and produce gamma interferon does not ensure recovery, but whether these CTLs were primed in the presence or absence of CD4(+) T-cell help (HCV-specific interleukin-2 production) is a critical determinant. These results have important implications for early prediction of the virologic outcome following acute HCV and for the development of novel immunotherapeutic approaches.
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