期刊
AMERICAN JOURNAL OF ROENTGENOLOGY
卷 196, 期 6, 页码 1351-1361出版社
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.10.5515
关键词
diffusion; MRI; oncology; perfusion
资金
- Cancer Research UK
- EPSRC Cancer Imaging Centre
- MRC and Department of HEalth (England) [C1060/A10334]
- National Health Service
- Cancer Research UK [12064] Funding Source: researchfish
OBJECTIVE. Diffusion-weighted MRI is increasingly applied in the body. It has been recognized for some time, on the basis of scientific experiments and studies in the brain, that the calculation of apparent diffusion coefficient by simple monoexponential relationship between MRI signal and b value does not fully account for tissue behavior. However, appreciation of this fact in body diffusion MRI is relatively new, because technologic advancements have only recently enabled high-quality body diffusion-weighted images to be acquired using multiple b values. There is now increasing interest in the radiologic community to apply more sophisticated analytic approaches, such as those based on the principles of intravoxel incoherent motion, which allows quantitative parameters that reflect tissue microcapillary perfusion and tissue diffusivity to be derived. CONCLUSION. In this review, we discuss the principles of intravoxel incoherent motion as applied to body diffusion-weighted MRI. The evidence for the technique in measuring tissue perfusion is presented and the emerging clinical utility surveyed. The requisites and challenges of quantitative evaluation beyond simple monoexponential relationships are highlighted.
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