期刊
AMERICAN JOURNAL OF ROENTGENOLOGY
卷 193, 期 2, 页码 314-325出版社
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.09.3107
关键词
cell tracking; immunotherapy; molecular imaging; stem cell therapy; superparamagnetic iron oxide
资金
- NIBIB NIH HHS [R21 EB005252-04, R01 EB007825, R01 EB007825-03, R21 EB005252] Funding Source: Medline
- NIDA NIH HHS [R01 DA026299, R01 DA02699, R01 DA026299-02] Funding Source: Medline
- NINDS NIH HHS [R01 NS045062, R01 NS045062-06A2] Funding Source: Medline
OBJECTIVE. The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION. Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
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