期刊
AMERICAN JOURNAL OF ROENTGENOLOGY
卷 190, 期 2, 页码 427-432出版社
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.07.2876
关键词
granuloma; lung cancer; perfusion imaging; PET/CT; radionuclides; tumor hypoxia
资金
- NCI NIH HHS [P01 CA42745-14, P01 CA042745, P01 CA042745-23, R44 CA110154] Funding Source: Medline
OBJECTIVE. Copper-diacetyl-bis(N-4-methylthiosemicarbazone)(Cu-ATSM) and copper-pyruvaldehyde-bis(N-4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e. g., Cu-62) has advantages for clinical PET, including a lower radiation dose than long-lived radionuclides and serial imaging capability. A Zn-62/Cu-62 microgenerator and rapid synthesis kits now provide a practical means of producing Cu-62-PTSM and Cu-62-ATSM on-site. Tumors can be characterized with Cu-62-PTSM, Cu-62-ATSM, and F-18-FDG PET scans during one session. We present the initial clinical data in two patients with lung neoplasms. CONCLUSION. Hypoxia and perfusion are important parameters in tumor physiology and can have major implications in diagnosis, prognosis, treatment planning, and response to therapy. We have shown the feasibility of performing 62Cu-ATSM and Cu-62-PTSM PET together with FDG PET/CT during a single imaging session to provide information on both perfusion and hypoxia and tumor anatomy and metabolism.
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