期刊
BRITISH JOURNAL OF NUTRITION
卷 99, 期 3, 页码 653-659出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S000711450782407X
关键词
phytanic acid; measurement; diet; dairy fat; EPIC-Oxford
资金
- Cancer Research UK Funding Source: Medline
- Medical Research Council Funding Source: Medline
Epidemiological data suggest that a diet rich in animal foods may be associated with an increased risk of several cancers, including cancers of the prostate, colorectum and breast, but the possible mechanism is unclear. It is hypothesised that phytanic acid, a C20 branched-chain fatty acid found predominantly in foods front ruminant animals, may be involved in early cancer development because it has been shown to up regulate activity of alpha-methylacyl-coenzyme A racemase, an enzyme commonly found to be over-expressed in tumour cells compared with normal tissue. However, little is known about the distribution of plasma phytanic acid concentrations or its dietary determinants in the general population. The primary aim of the present cross-sectional study was to determine circulating phytanic acid concentrations among ninety-six meat-eating, lacto-ovo-vegetarian and vegan women, aged 20-69 years, recruited into the Oxford component of the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). Meat-eaters had, on average, a 6.7-fold higher geometric mean plasma phytanic acid concentration than the vegans (5-77 v. 0-86 mu mol/l; P < 0.0001) and a 47 % higher mean concentration than the vegetarians (5-77 v. 3-93 mu mol/l; P=0-016). The strongest determinant of plasma phytanic acid concentration appeared to be dairy fat intake (r 0.68; P < 0.0001); phytanic acid levels were not associated with age or other lifestyle factors. These data show that a diet high in fat from dairy products is associated with increased plasma phytanic acid concentration, which may play a role in cancer development.
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