期刊
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
卷 185, 期 9, 页码 911-917出版社
AMER THORACIC SOC
DOI: 10.1164/rccm.201107-1320OE
关键词
neuromuscular blockade; intensive care unit-acquired weakness; outcome
资金
- Department of Health [DRF-2010-03-114] Funding Source: Medline
- National Institute for Health Research [ACF-2010-17-001, DRF-2010-03-114] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [DRF-2010-03-114] Funding Source: National Institutes of Health Research (NIHR)
Neuromuscular blocking agents are commonly used in critical care. However, concern after observational reports of a causal relationship with skeletal muscle dysfunction and intensive care-acquired weakness (ICU-AW) has resulted n a cautionary and conservative approach to their use. This integrative review, interpreted in the context of our current understanding of the pathophysiology of ICU-AW and integrated into our current conceptual framework of clinical practice, challenges the established clinical view of an adverse relationship between the use of neuromuscular blocking agents and skeletal muscle weakness. In addition to discussing data, this review identifies potential con founders and alternative etiological factors responsible for ICU-AW and provides evidence that neuromuscular blocking agents may not be a major cause of weakness in a 21st century critical care setting.
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