期刊
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
卷 182, 期 6, 页码 819-825出版社
AMER THORACIC SOC
DOI: 10.1164/rccm.200912-1797OC
关键词
particulate matter; sleep-disordered breathing; sleep architecture
资金
- SHHS [U01 HL63463]
- NIEHS [P01 ES09825]
- EPA [RD832416]
- U.S. Environmental Protection Agency [RD832416]
- Dymedix Inc
- EPA
- American Sleep and Breathing Institute
- Health Right Products
- Health Effects Institute
- American Chemistry Council
Rationale: Sleep-disordered breathing (SDB), the recurrent episodic disruption of normal breathing during sleep, affects as much as 17% of U.S. adults, and may be more prevalent in poor urban environments. SDB and air pollution have been linked to increased cardiovascular diseases and mortality, but the association between pollution and SDB is poorly understood. Objectives: We used data from the Sleep Heart Health Study (SHHS), a U.S. multicenter cohort study assessing cardiovascular and other consequences of SDB, to examine whether particulate air matter less than 10 mu m in aerodynamic diameter (PM10) was associated with SDB among persons 39 years of age and older. Methods: Using baseline data from SHHS urban sites, outcomes included the following: the respiratory disturbance index (RDI); percentage of sleep time at less than 90% O-2 saturation; and sleep efficiency, measured by overnight in-home polysomnography. We applied a fixed-effect model containing a city effect, controlling for potential predictors. In all models we included both the 365-day moving averages of PM10, and temperature (long-term effects) and the differences between the daily measures of these two predictors and their 365-day average (short-term effects). Measurements and Main Results: In summer, increases in RDI or percentage of sleep time at less than 90% O-2 saturation, and decreases in sleep efficiency, were all associated with increases in short-term variation in PM10. Over all seasons, we found that increased RDI was associated with an 11.5% (95% confidence interval: 1.96, 22.01) increase per interquartile range increase (25.5 degrees F) in temperature. Conclusions: Reduction in air pollution exposure may decrease the severity of SDB and nocturnal hypoxemia and may improve cardiac risk.
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