期刊
JOURNAL OF VIROLOGY
卷 82, 期 6, 页码 3154-3160出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02474-07
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资金
- NIAID NIH HHS [R01 AI067926, R01-AI067926-01, R01-AI031563-13, K23-AI054379-05, U19-AI066345-02, U19 AI066345, K23 AI054379, R01 AI031563] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
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