期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 72, 期 4, 页码 359-375出版社
WILEY
DOI: 10.1111/aji.12275
关键词
Embryonic development; first trimester; long non-coding RNA (lncRNA); pathogenesis; pathways; spontaneous abortion
资金
- Shijiazhuang Maternal and Obstetric Hospital
- March of Dimes Global Network for Maternal and Infant Health (MOD-GNMIH), Peking University Center of Medical Genetics (PUCMG)
- New York State Office for People with Developmental Disabilities (NYS OPWDD)
Problem Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been investigated the possible involvement of lncRNA in pregnancy loss. Method of StudySixteen pairs of pregnancies with spontaneous abortions (SA) and induced abortions (IA) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human LncRNA Array was employed to profile genomewide lncRNAs, which were then validated by RT-PCR. ResultsDifferentially expressed lncRNAs were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation. ConclusionsInfection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.
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