期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 71, 期 6, 页码 575-588出版社
WILEY
DOI: 10.1111/aji.12250
关键词
Antimicrobials; cervical-vaginal lavage; female reproductive tract; HIV; hormones; sexually transmitted infections
The mucosal microenvironment of the female reproductive tract (FRT) is rich in secreted endogenous antimicrobials that provide the first line of defense against pathogens. This review focuses on the spectrum of secreted antimicrobials found in the FRT that have anti-HIV functions and are regulated by the natural hormonal changes in women's life cycle. Understanding the complex nature of FRT, mucosal microenvironment will enable us to better design therapeutic interventions for women against sexually transmitted pathogens.
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