期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 73, 期 1, 页码 36-55出版社
WILEY
DOI: 10.1111/aji.12328
关键词
Chemokines; choriodecidua; miRNAs; pathway analysis; transcription factors
资金
- James Tudor Foundation
- Tommy's the Baby Charity
- Ferring
- Action Medical Research Endowment
- Manchester Biomedical Research Centre
- Greater Manchester Comprehensive Research Network
ProblemInflammation is a driver of labor in myometrium and cervix; however, the involvement of decidua is poorly defined. We have reported decidual leukocyte infiltration prior to and during labor; the regulators of these inflammatory processes are unknown. Method of studyChoriodecidua RNA obtained after term labor or elective cesarean delivery was applied to Affymetrix GeneChips. Pathway analysis and gene validation were performed. ResultsExtensive inflammatory activation was identified in choriodecidua following labor, predominantly upregulation of genes regulating leukocyte trafficking and cytokine signalling. Genes governing cell fate, tissue remodelling, and translation were also altered. Upregulation of candidate genes (ICAM1, CXCR4, CD44, TLR4, SOCS3, BCL2A, and IDO) was confirmed. NFB, STAT1&3, HMGB1, and miRNA-21, miRNA-46, miRNA-141, and miRNA-200 were predicted upstream regulators. ConclusionThis study confirms inflammatory processes are major players in labor events in choriodecidua, as in other gestational tissues. Suppressing uterine inflammation is likely to be critical for arresting premature labor.
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