期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 71, 期 2, 页码 95-108出版社
WILEY
DOI: 10.1111/aji.12182
关键词
CTL; endocervix; endometrium; HIV; STD; T-cell
资金
- NIH [NIH/NIAID P01 AI083050]
ProblemThe goal of this study was to investigate the phenotype and functional responsiveness of CD4(+) and CD8(+) T-cells in the upper reproductive tract of healthy premenopausal women. The lower reproductive tract is frequently studied as a site of sexually transmitted infections; however, the upper reproductive tract may also be a portal of entry and dissemination for pathogens, including HIV-1. Method of StudyEndometrial biopsy, endocervical curettage, cytobrush, and blood were collected during mid-luteal phase from 23 healthy women. T-cells were isolated and analyzed by flow cytometry. ResultsAs compared with their counterparts in blood, endometrial and endocervical T-cells had enhanced CCR5 expression, and were enriched for activated, effector memory cells. Endometrial T-cells were more responsive to polyclonal stimuli, producing a broad range of cytokines and chemokines. ConclusionThese findings underscore the responsiveness of endometrial T-cells to stimulation, and reveal their activated phenotype. These findings also suggest susceptibility of the upper reproductive tract to HIV-1 infection.
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