期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 71, 期 1, 页码 55-60出版社
WILEY
DOI: 10.1111/aji.12162
关键词
Activation fragment Bb; alternative complement pathway; severe Preeclampsia
资金
- NIH/NCATS Colorado CTSI Grant [UL1 TR000154]
- University of Colorado Denver Department of Obstetrics and Gynecology Academic Enrichment Fund Grant
- National Institutes of Health/NICHD [R01 HD60723]
ProblemWe sought to determine whether alternative complement activation fragment Bb (Bb) levels are elevated in the maternal, fetal, and placental blood in cases of severe preeclampsia (PE) compared with normotensive controls. Method of studyThis was a cross-sectional study of women admitted at 24weeks gestation with or without severe PE. Maternal plasma was collected at the time of enrollment. Umbilical venous cord and intervillous space blood were collected at delivery. Plasma Bb levels were assessed using ELISA. Bb levels were compared between cases and controls. ResultsMedian Bb levels were higher in the maternal plasma of severe PE subjects (n=24) than in controls (n=20), 1.451.03 versus 0.65 +/- 0.23g/mL, P<0.001. In umbilical venous plasma, Bb levels were higher in severe PE subjects (n=15) compared with controls (n=15), 2.48 +/- 1.40 versus 1.01 +/- 0.57g/mL, P=0.01. ConclusionActivation fragment Bb is increased in the maternal and umbilical venous blood of cases of severe PE when compared with normotensive controls. These data provide support for alternative complement pathway involvement in the pathogenesis of severe PE and demonstrate that alternative complement activation occurs not only in the maternal but also in the fetal compartment.
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