期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 68, 期 2, 页码 175-180出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0897.2012.01145.x
关键词
CD25; FoxP3; pre-eclampsia; pregnancy; Treg
资金
- Hungarian Academy of Sciences
- [OTKA 101661]
- [TAMOP-4.2.2.-08/1/KMR-2008-0004]
- Grants-in-Aid for Scientific Research [23390386] Funding Source: KAKEN
Problem Regulatory T cells (Tregs) play an important role in the development of pregnancy-specific immune tolerance. We aimed to determine the peripheral frequency of a recently described Treg subpopulation, the CD4+ CD25- FoxP3+ Treg subset, and its correlation with the conventional CD4+ CD25high FoxP3+ Tregs in normal pregnancy (NP) and pre-eclampsia (PE) compared to non-pregnant (non-P) women. We also examined the proportion of the activated CD4+ CD25high FoxP3high Treg subset within conventional Treg cells. Method We took peripheral blood samples from 20 PE, 20 NP, and 12 non-P women and determined the frequency of the above Treg subsets using flow cytometry. Results The frequency of conventional CD4+ CD25high FoxP3+ Tregs and activated CD4+ CD25high FoxP3high Tregs, but also that of non-conventional CD4+ CD25- FoxP3+ Tregs was higher in NP compared to non-P women, but lower again in PE, reaching comparable levels to the non-P group. The ratios of CD4+ CD25high FoxP3+ and CD4+ CD25- FoxP3+ Treg subsets were constant in all three investigated groups. Conclusion Our results indicate that the frequency of conventional and non-conventional Tregs alters simultaneously, and the presence in circulation of both of these Treg subsets is similarly important in the adequate development of pregnancy-specific immune tolerance.
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