期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 66, 期 -, 页码 88-92出版社
WILEY
DOI: 10.1111/j.1600-0897.2011.01040.x
关键词
Interleukin-10; pre-eclampsia; pregnancy; regulatory T cells; vascular activity
资金
- National Institutes of Health [P20RR018728]
- Rhode Island Research Alliance
Problem Regulatory T cells (T-reg) are a vital immune cellular population at the maternal-fetal interface. They are likely to aid in immune tolerance by dampening the harmful effects of other immune cellular populations through cell-cell-mediated interactions as well as by producing IL-10 and TGF-beta. In addition to the anti-inflammatory properties, IL-10 has emerged as an important vascular cytokine choreographing endovascular interactions and angiogenesis and regulates hypertension. Method of study Review of innovative concepts to understand the temporal role of T-regs in both mouse and human pregnancy, particularly whether uterine T-reg play a potential role in regulating vascular homeostasis and blood flow during pregnancy. Results T-reg guard immune tolerance, getting cytotoxically activated under certain conditions, leading to adverse pregnancy outcome. Conclusion Despite increasing evidence of T(reg)tissue-specific expansion and functional plasticity, their role in vascular activity, pre-eclampsia or gestational diabetes is obscure and needs closer investigation to delineate its role later during pregnancy.
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