4.4 Article

Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice

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AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 65, 期 2, 页码 104-109

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WILEY-BLACKWELL
DOI: 10.1111/j.1600-0897.2010.00896.x

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Abortion; anticoagulant; IL-6; VEGF; Vitamin E

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Problem Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Method of study Pregnant females from CBA/J x DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Results Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Conclusion Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.

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