期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 63, 期 6, 页码 587-600出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0897.2010.00848.x
关键词
Fetus; pre-eclampsia; pregnancy; preterm labor; TLR; trophoblast
资金
- National Institute of Health, NICDH [P01HD054713, 3N01 HD23342]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services
Toll-like receptors (TLR) form the major family of pattern recognition receptors (PRR) that are involved in innate immunity. Innate immune responses against microorganisms at the maternal-fetal interface may have a significant impact on the success of pregnancy, as intrauterine infections have been shown to be strongly associated with certain disorders of pregnancy. At the maternal-fetal interface, TLRs are expressed not only in the immune cells but also in non-immune cells such as trophoblasts and decidual cells; moreover, their expression patterns vary according to the stage of pregnancy. Here, we will describe potential functions of TLRs in these cells, their recognition and response to microorganisms, and their involvement in the innate immunity. The impact of TLR-mediated innate immune response will be discussed via animal model studies, as well as clinical observations.
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