期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 63, 期 6, 页码 434-444出版社
WILEY
DOI: 10.1111/j.1600-0897.2009.00794.x
关键词
Decidual NK cells; endometrial NK cells; pregnancy
资金
- Israel Science Foundation
- European consortium [LSHC-CT-2005-518178, MRTN-CT-2005]
- ICRF
- BSF
P>Natural killer (NK) cells are lymphocytes of the innate immunity system that are able to kill various hazardous pathogens and tumors. However, it is now widely accepted that NK cells also possess non-destructive functions, as has been demonstrated for uterine NK cells. Here, we review the unique properties of the NK cells in the uterine mucosa, prior to and during pregnancy. We discuss the phenotype and function of mouse and human endometrial and decidual NK cells and suggest that the major function of decidual NK cells is to assist in fetal development. We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy.
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