期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 62, 期 2, 页码 112-117出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-0897.2009.00718.x
关键词
Cytokines; inflammation; interleukin-1; leiomyoma; polymorphism; tumor
Problem To investigate whether polymorphisms in the interleukin-1 beta (IL-1 beta) gene are associated with uterine leiomyoma. Method of study Case-control study in a collective of 131 patients and 280 controls. Genotyping of the IL-1 beta-511 and IL-1 beta-3954 polymorphism was performed by PCR amplification and subsequent RFLP analysis. Results A significant difference in the allele frequencies of the IL-1 beta-511 C < T polymorphism was found. Allele frequencies of the IL-1 beta-511 C < T polymorphism were 70.6% (C allele) in the patient group and 57.1% in the control group [P < 0.0002; odds ratio (OR) 1.81; 95% confidence interval (CI): 1.32-2.47]. The genotype distributions showed also differences using a dominant genotype model (C/C vs. C/T+T/T; P < 0.0002; OR 2.73; 95% CI: 1.77-4.2). No difference was found in the IL-1 beta-3954 polymorphism. Conclusion The IL-1 beta-511 promoter polymorphism is related to an increased susceptibility to uterine leiomyoma, suggesting that this polymorphism does contribute to the development of this disease.
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