期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 83, 期 3, 页码 518-522出版社
WILEY
DOI: 10.1189/jlb.0607369
关键词
ER-a; ER-beta; cytokines; shock; cell signaling; Kupffer cells
资金
- NIAAA NIH HHS [R01 AA 015731-01A2] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 37127, R37 GM 39519] Funding Source: Medline
17 beta-Estradiol (i.e., estrogen or E2) is a female sex steroid, which plays an essential role in female reproductive physiology. However, several lines of evidence indicate that in addition to its role in reproductive physiology, E2 is critical for maintaining many other organ functions in stress conditions. These include immune, cardiovascular, and neuronal functions, as well as regulation of skin, bone, and lipid metabolism. Studies have examined the role of E2 as an adjunct in post-trauma responses, and this article will review whether E2 as an adjunct to fluid resuscitation following trauma-hemorrhage plays any role in improving/restoring immune and cardiovascular functions.
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