期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 102, 期 1, 页码 25-34出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-015-1783-3
关键词
VPS4B; CAM-DR; PI3K/Akt; MAPK/ERK; Proliferation
类别
资金
- National Natural Science Foundation of China [81201858, 81172879, 81372537]
- Natural Science Foundation of Jiangsu province [BK2012231]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The expression and biologic function of the gene encoding vacuolar protein sorting 4B (VPS4B) in human multiple myeloma (MM) were investigated in this study. We determined that VPS4B expression is decreased in adherent MM cells and that knockdown of VPS4B expression induces cell adhesion-mediated drug resistance (CAM-DR) in MM. This induced CAM-DR phenotype manifested through down-regulation of cell apoptosis and requires phosphorylation of AKT and Erk. Finally, VPS4B expression was positively correlated with cell proliferation. Our findings support a role for VPS4B in MM cell proliferation, adhesion, and drug resistance, and pave the way for a novel therapeutic approach targeting this molecule.
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