期刊
AMERICAN JOURNAL OF PUBLIC HEALTH
卷 102, 期 2, 页码 269-276出版社
AMER PUBLIC HEALTH ASSOC INC
DOI: 10.2105/AJPH.2011.300218
关键词
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资金
- Vaccine Modeling Initiative
- Bill and Melinda Gates Foundation
- National Institute of General Medical Sciences [1U54GM088491-0109]
Objectives. We investigated whether introducing the rotavirus and pneumococcal vaccines, which are greatly needed in West Africa, would overwhelm existing supply chains (i.e., the series of steps required to get a vaccine from the manufacturers to the target population) in Niger. Methods. As part of the Bill and Melinda Gates Foundation funded Vaccine Modeling Initiative, we developed a computational model to determine the impact of introducing these new vaccines to Niger's Expanded Program on Immunization vaccine supply chain. Results. Introducing either the rotavirus vaccine or the 7-valent pneumococcal conjugate vaccine could overwhelm available storage and transport refrigerator space, creating bottlenecks that would prevent the flow of vaccines down to the clinics. As a result, the availability of all World Health Organization Expanded Program on Immunization vaccines to patients might decrease from an average of 69% to 28.2% (range=10%-51%). Addition of refrigerator and transport capacity could alleviate this bottleneck. Conclusions. Our results suggest that the effects on the vaccine supply chain should be considered when introducing a new vaccine and that computational models can help assess evolving needs and prevent problems with vaccine delivery. (Am J Public Health. 2012;102:269-276. doi:10.2105/AJPH.2011.300218)
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