期刊
AMERICAN JOURNAL OF PUBLIC HEALTH
卷 101, 期 -, 页码 S333-S338出版社
AMER PUBLIC HEALTH ASSOC INC
DOI: 10.2105/AJPH.2010.300025
关键词
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资金
- Swedish International Development Cooperation Agency (Sida)
- Swedish Research Council
- Formas
- European Commission [FOOD-CT-2006-016253]
- Karolinska Institute
- United Nations Children's Fund
- UK Medical Research Council
- Department for International Development
- ICDDR,B
- Global Health Research Fund-Japan
- Child Health and Nutrition Research Initiative, Uppsala University
- US Agency for International Development
Objectives. Elevated arsenic levels in tube-well water in Bangladesh have prompted extensive mitigation projects. We evaluated the effectiveness of long-term mitigation efforts by longitudinally measuring arsenic exposure in pregnant women and their children, the most susceptible population groups. Methods. The study was nested in a population-based nutrition intervention in Mat lab, Bangladesh. Mother child pairs (n=1951) were followed from 2001 to 2003, beginning in early gestation and continuing to 5 years postpartum. We measured arsenic concentrations in urine (U-As) of the 5-year-old children by using high-performance liquid chromatography online with hydride generation and inductively coupled plasma mass spectrometry and compared them with earlier childhood U-As and maternal U-As during pregnancy. Results. Children had elevated U-As at 5 years old (median=51 mu g/L, 5th-95th percentiles=16-355 mu g/L), and U-As distribution was similar to that observed in the mothers during gestation. Children's U-As at 5 years old significantly correlated with their U-As at 1.5 years old and to maternal U-As during early and late gestation. Conclusions. Despite major mitigation efforts, arsenic exposure remains highly elevated in rural Bangladesh. Further mitigation strategies are required and must be rigorously evaluated for long-term efficacy. (Am J Public Health. 2011;101:S333-S338. doi:10.2105/AJPH.2010.300025)
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