期刊
MOLECULAR ONCOLOGY
卷 1, 期 4, 页码 431-439出版社
WILEY
DOI: 10.1016/j.molonc.2007.08.002
关键词
Calcium binding proteins; Tissue microarray; Gene silencing; ALG-2
类别
资金
- Danish Research Council
- Danish Cancer Society
- Lundbeck Foundation
The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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