期刊
AMERICAN JOURNAL OF PSYCHIATRY
卷 170, 期 8, 页码 852-859出版社
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.2012.12070971
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资金
- ETS grant from the Spanish Ministry of Economy and Competitiveness [PI080180, PI08/90825, PI08/90327, PI08/90675, PI08/90224, PI08/90654, PI08/90189, PI08/90916, PI08/90416, PI08/90094]
- Carlos III Health Institute
- General Subdepartment for Evaluation and Research Promotion
- European Regional Fund
- European Union
- Una manera de hacer Europa
- CIBERSAM
- Commissioner for Universities and Research, Ministry of Innovation, Universities and Enterprise, Catalan Government [2009 SGR 1022]
- Almirall
- AstraZeneca
- Bristol-Myers Squibb
- Cephalon
- Eli Lilly
- GlaxoSmithKline
- Janssen-Cilag
- Lundbeck
- Merck
- Novartis
- Otsuka
- Pfizer
- Sanofi-Aventis
- Schering-Plough
- Spanish Ministry of Science and Innovation (CIBERSAM)
- FIS
- Health Ministry, IDIBELL Foundation
- Abbott
- AMGEN
- Caja Navarra
- Alicia Koplowitz Foundation
- Ministry of Science and Innovation
- Ministry of Health
- Ministry of Economy and Competitiveness
- Mutua Madrilena
- Roche
- Servier
- Takeda
- Cambridge University Press
- Solal Ed
- Ars Medica
- Giovani Fioriti Ed
- Medipage
- La Esfera de Los Libros
- Morales i Torres Ed
- Panamericana
- Mayo Ed.
- Columna
- Spanish Ministry of Economy and Competitiveness
- Alicia Koplowitz Grant for Short-Term Placements from the Alicia Koplowitz Foundation
- AGAUR
- Boehringer-Ingelheim
- Janssen
- Medtronic
- Rovi
- Spanish Ministry of Health
- Spanish Ministry of Science and Innovation
- Wyeth
- Alexza
- Ferrer
- Forest Research Institute
- Gedeon Richter
- Jazz
- Johnson Johnson
- Organon
- Pierre-Fabre
- Qualigen
- Shire
- Solvay
- Seventh European Framework Programme (ENBREC)
- Stanley Medical Research Institute
- United Biosource Corporation
Objective: The authors sought to assess the efficacy of functional remediation, a novel intervention program, on functional improvement in a sample of euthymic patients with bipolar disorder. Method: In a multicenter, randomized, rater-blind clinical trial involving 239 outpatients with DSM-IV bipolar disorder, functional remediation (N=77) was compared with psychoeducation (N=82) and treatment as usual (N=80) over 21 weeks. Pharmacological treatment was kept stable in all three groups. The primary outcome measure was improvement in global psychosocial functioning, measured blindly as the mean change in score on the Functioning Assessment Short Test from baseline to endpoint. Results: At the end of the study, 183 patients completed the treatment phase. Repeated-measures analysis revealed significant functional improvement from baseline to endpoint over the 21 weeks of treatment (last observation carried forward), suggesting an interaction between treatment assignment and time. Tukey's post hoc tests revealed that functional remediation differed significantly from treatment as usual, but not from psychoeducation. Conclusions: Functional remediation, a novel group intervention, showed efficacy in improving the functional outcome of a sample of euthymic bipolar patients as compared with treatment as usual.
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