期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 28, 期 4, 页码 764-771出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/sj.jcbfm.9600573
关键词
angiogenesis; neurogenesis; stroke; rat; VEGF
资金
- NHLBI NIH HHS [R01 HL064766-06, R01 HL064766, R01HL 64766] Funding Source: Medline
- NINDS NIH HHS [P01 NS023393, P01 NS42345, R01 NS038292, P01 NS042345-059002, R01NS38292, P01 NS042345, P01 NS023393-17, P01 NS23393, R01 NS038292-02] Funding Source: Medline
Angiogenesis and neurogenesis are coupled processes. Using a coculture system, we tested the hypothesis that cerebral endothelial cells activated by ischemia enhance neural progenitor cell proliferation and differentiation, while neural progenitor cells isolated from the ischemic subventricular zone promote angiogenesis. Coculture of neural progenitor cells isolated from the subventricular zone of the adult normal rat with cerebral endothelial cells isolated from the stroke boundary substantially increased neural progenitor cell proliferation and neuronal differentiation and reduced astrocytic differentiation. Conditioned medium harvested from the stroke neural progenitor cells promoted capillary tube formation of normal cerebral endothelial cells. Blockage of vascular endothelial growth factor receptor 2 suppressed the effect of the endothelial cells activated by stroke on neurogenesis as well as the effect of the supernatant obtained from stroke neural progenitor cells on angiogenesis. These data suggest that angiogenesis couples to neurogenesis after stroke and vascular endothelial growth factor likely mediates this coupling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据