4.6 Article

The Columbia-Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults

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AMERICAN JOURNAL OF PSYCHIATRY
卷 168, 期 12, 页码 1266-1277

出版社

AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.2011.10111704

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资金

  1. ERT, Inc.
  2. Abbott
  3. Albany Molecular Research
  4. Alfresa
  5. Alkermes
  6. Amgen
  7. AstraZeneca
  8. Biodelivery Sciences International
  9. Biomarin
  10. Bristol-Myers Squibb
  11. Canam
  12. Cato Research
  13. Cephalon
  14. Cetero Research
  15. Covance
  16. CRI Worldwide
  17. Depomed
  18. Douglas Pharmaceuticals
  19. Eisai
  20. Euthymics
  21. Forest
  22. GlaxoSmithKline
  23. GW Pharma
  24. Human Genome Sciences
  25. i3 Research,
  26. ICON
  27. IntelGenx
  28. Intracellular Therapies
  29. Johnson Johnson
  30. Kendle Early Stage
  31. Lilly USA
  32. Lundbeck A/S
  33. Lundbeck USA
  34. Medlmmune
  35. Medtronic
  36. Merck
  37. Neurosearch
  38. Next Wave Pharmaceuticals
  39. Novartis
  40. Noven
  41. NovoNordisk
  42. Orexigen
  43. Otsuka
  44. Parexel
  45. Pfizer
  46. PGx Health
  47. Pharmaceutical Product Development, Inc.
  48. Psyadon
  49. QED
  50. Quintiles
  51. Reckitt Benckiser
  52. Roche
  53. Sanofi-Aventis
  54. Schering-Plough
  55. SCOPE international
  56. sepracor/Sunovion
  57. Shire
  58. Siena Biotech
  59. Supernus
  60. Synosia Therapeutics
  61. Takeda
  62. Theravance
  63. Upsher-Smith
  64. Valeant
  65. Vivus
  66. World Wide Clinical Trials
  67. Wyeth Research
  68. NIMH
  69. Guilford Press
  70. Eli Lilly
  71. Janssen
  72. Otsuko
  73. Rhodes Pharmaceutical
  74. National Institute on Drug Abuse
  75. NIMH [MH66750, MH66769, MH66762, MH66775, MH66778]
  76. American Foundation for Suicide Prevention
  77. National Institute on Alcohol Abuse and Alcoholism Developing Centers on Interventions for the Prevention of Suicide [5 P20 AA015630]

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Objective: Research on suicide prevention and interventions requires a standard method for assessing both suicidal ideation and behavior to identify those at risk and to track treatment response. The Columbia Suicide Severity Rating Scale (C-SSRS) was designed to quantify the severity of suicidal ideation and behavior. The authors examined the psychometric properties of the scale. Method: The C-SSRS's validity relative to other measures of suicidal ideation and behavior and the internal consistency of its intensity of ideation subscale were analyzed in three multisite studies: a treatment study of adolescent suicide attempters (N=124); a medication efficacy trial with depressed adolescents (N=312); and a study of adults presenting to an emergency department for psychiatric reasons (N=237). Results: The C-SSRS demonstrated good convergent and divergent validity with other multi-informant suicidal ideation and behavior scales and had high sensitivity and specificity for suicidal behavior classifications compared with another behavior scale and an independent suicide evaluation board. Both the ideation and behavior subscales were sensitive to change over time. The intensity of ideation subscale demonstrated moderate to strong internal consistency. In the adolescent suicide attempters study, worst-point lifetime suicidal ideation on the C-SSRS predicted suicide attempts during the study, whereas the Scale for Suicide Ideation did not. Participants with the two highest levels of ideation severity (intent or intent with plan) at baseline had higher odds for attempting suicide during the study. Conclusions: These findings suggest that the C-SSRS is suitable for assessment of suicidal ideation and behavior in clinical and research settings.

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