期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 25, 页码 13866-13875出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b02077
关键词
magnetic hyperthermia ablation; injectable; biodegradable; calcium phosphate; cement; tumor
资金
- National Science Fund for Distinguished Young Scholars [81425014]
- 973 program [2014CB744500]
- National Nature Science Fund of China [81270021, 8271598]
- Chongqing Science Fund for Distinguished Young Scholars [cstc2013jcyjjq10004]
- Program for New Century Excellent Talents in University of Ministry of Education of China [NCET-13-1067]
- Key Grant of Education Commission of Chongqing [KJ120328]
- Key Grant of Chinese Ministry of Education [212142]
In this work, we have developed an injectable and biodegradable material using CPC containing Fe3O4 nanoparticles for minimally invasive and efficiently magnetic hyperthermia ablation of tumors. When exposed to an alternating magnetic field, the MCPC could quickly generate heat. The temperature of PBS and the excised bovine liver increased with the MCPC weight, iron content, and time. The ablated liver tissue volume for 0.36 g of 10% MCPC was 0.2 +/- 0.03, 1.01 +/- 0.07, and 1.96 +/- 0.19 cm(3), respectively, at the time point of 60, 180, and 300 s. In our in vivo experiment, the MCPC could be directly injected into the center of the tumors under the guidance of ultrasound imaging. The formed MCPC was well-restricted within the tumor tissues without leakage, and the tumors were completely ablated by 0.36 g of 10% injectable MCPC after 180 s of induction heating.
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