期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 307, 期 5, 页码 R487-R489出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00177.2014
关键词
angiotensin II; angiotensin-(1-7); kidney; metabolism; peptidase; fetal programming
类别
资金
- National Institutes of Health [HL-56973, HL-52972, HL-112237, HD-047584]
- American Heart Association [GRNT20480131]
The kidney is a key target organ for bioactive components of the renin-angiotensin system (RAS); however, various renal cells such as the tubular epithelium contain an intrinsic RAS. The renal RAS can be functionally divided into ANG II-AT(1) receptor and ANG-(1-7)-AT(7)/Mas receptor arms that functionally oppose one another. The current review considers both extracellular and intracellular pathways that potentially govern the formation and metabolism of angiotensin peptides within the renal proximal tubules.
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