期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 298, 期 1, 页码 R183-R190出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00176.2009
关键词
interleukin-6; blood pressure
类别
资金
- KAKENHI [19599022, 19.07458, 20590236]
- British Heart Foundation [RG/07/006/23634] Funding Source: researchfish
Takagishi M, Waki H, Bhuiyan ME, Gouraud SS, Kohsaka A, Cui H, Yamazaki T, Paton JF, Maeda M. IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats. Am J Physiol Regul Integr Comp Physiol 298: R183-R190, 2010. First published November 11, 2009; doi:10.1152/ajpregu.00176.2009.-Recent gene array and molecular studies have suggested that an abnormal gene expression profile of interleukin-6 (IL-6) in the nucleus tractus solitarii (NTS), a pivotal region for regulating arterial pressure, may be related to the development of neurogenic hypertension. However, the precise functional role of IL-6 in the NTS remains unknown. In the present study, we have tested whether IL-6 affects cardiovascular control at the level of the NTS. IL-6 (1, 10, and 100 fmol) was microinjected in the NTS of Wistar rats (280-350 g) under urethane anesthesia. Although the baseline levels of arterial pressure and heart rate did not change following IL-6 injections, the cardiac baroreflex in response to increased arterial pressure was dose-dependently attenuated. In addition, IL-6 (100 fmol) microinjections also attenuated L-glutamate-induced bradycardia at the level of the NTS. Immunohistochemical detection of IL-6 in naive rats demonstrated that it was predominantly observed in neurons within the brain stem, including the NTS. These findings suggest that IL-6 within the NTS may play an important role for regulating cardiovascular control via modulation of input signals from baroreceptor afferents. Whether the abnormal gene expression of IL-6 in the NTS is associated in a causal way with hypertension remains to be resolved.
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