期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 298, 期 2, 页码 R266-R271出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00471.2009
关键词
F2-isoprostanes; lucigenin chemiluminescence; sexual dimorphism; hypertension; catalase; prooxidant
类别
资金
- NHLBI NIH HHS [P01 HL051971, HL69194, HL51971, HL66072, R01 HL066072] Funding Source: Medline
Lopez-Ruiz AF, Iliescu R, Reckelhoff JF. Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes. Am J Physiol Regul Integr Comp Physiol 297: R266-R271, 2010. First published December 16, 2009; doi:10.1152/ajpregu.00471.2009.-There is a sex difference in the blood pressure (BP) responses to prooxidants and antioxidants in the spontaneously hypertensive rat (SHR). In contrast to males, BP in female SHR does not decrease in response to antioxidants, such as tempol or apocynin, or increase in response to the prooxidant, molsidomine. Molsidomine decreases BP and increases expression of antioxidants in male Wistar-Kyoto rats (WKY), but not male SHR. The present study tested the hypothesis that the mechanism responsible for the lack of a pressor response to molsidomine in females is due to higher endogenous nitric oxide (NO) or to compensatory upregulation of renal antioxidant enzymes. Female SHR were treated with molsidomine in the presence or absence of nitro-L-arginine methyl ester (L-NAME) for 2 wk. Molsidomine increased nitrate/nitrite (NOx) and F2-isoprostane (F2-IsoP) excretion, whereas L-NAME reduced NOx but increased F-Isop. Molsidomine and L-NAME together further reduced NOx and increased F2-IsoP. Molsidomine alone had no effect on BP; L-NAME alone increased BP. The combination of molsidomine and L-NAME did not increase BP above L-NAME alone levels. Whole body and renal oxidative stress increased, while renal cortical Cu, Zn-SOD expression was downregulated and catalase was upregulated by molsidomine; glutathione peroxidase expression was unaffected. These data support our previous studies suggesting that BP in female SHR is independent of either increases or decreases in oxidative stress. The mechanisms responsible for the sex difference in BP response to increase or decrease of oxidative stress are not due to increased NO in females or to compensatory upregulation of antioxidant enzymes in response to increases in oxidants.
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