期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 5, 页码 391-397出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2315
关键词
-
类别
资金
- Medical Research Council [G117/515] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G117/515] Funding Source: UKRI
- Medical Research Council [G117/515] Funding Source: researchfish
When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据