期刊
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
卷 302, 期 9, 页码 L803-L815出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00355.2011
关键词
pulmonary vascular dysfunction; right ventricular failure; microvascular occlusion; hypoxic vasoconstriction; pulmonary vascular remodeling
资金
- National Institute for Health Research Respiratory Disease Biomedical Research Unit at the Royal Brompton
- Harefield National Health Service (NHS) Foundation Trust
- Imperial College London
- British Heart Foundation
- Northern Ireland Public Health Agency, Research and Development Division Translational Research Group for Critical Care
Price LC, McAuley DF, Marino PS, Finney SJ, Griffiths MJ, Wort SJ. Pathophysiology of pulmonary hypertension in acute lung injury. Am J Physiol Lung Cell Mol Physiol 302: L803-L815, 2012. First published January 13, 2012; doi: 10.1152/ajplung.00355.2011.-Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein rich alveolar edema, reduced lung compliance, and acute severe hypoxemia. A degree of pulmonary hypertension (PH) is also characteristic, higher levels of which are associated with increased morbidity and mortality. The increase in right ventricular (RV) afterload causes RV dysfunction and failure in some patients, with associated adverse effects on oxygen delivery. Although the introduction of lung protective ventilation strategies has probably reduced the severity of PH in ALI, a recent invasive hemodynamic analysis suggests that even in the modern era, its presence remains clinically important. We therefore sought to summarize current knowledge of the pathophysiology of PH in ALI.
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