期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 306, 期 8, 页码 H1105-H1115出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00645.2013
关键词
vascular reactivity; sex; age; estrogen; estrogen receptor; Rho kinase; PKC
资金
- National Natural Science Foundation of China [30830053]
- Major State Basic Research Program [2012CB518101]
- Chongqing Scientific Foundation for Distinguished Young Scholars [cstc2011jjjq0019]
- State Key Laboratory Foundation [SKLZZ200901, 201006, 201109, 200912]
Several medical conditions exhibit age-and sex-based differences. Whether or not traumatic shock exhibits such differences with regard to vascular responsiveness is not clear. In a cohort of 177 healthy subjects and 842 trauma patients (21-82 years) as well as different ages (4, 8, 10, 14, 18, and 24 wk; 1 and 1.5 years) and sexes of Sprague-Dawley normal and traumatic shock rats, the age-and sex-based differences of vascular responsiveness and the underlying mechanisms were investigated. Middle-aged and young women as well as female rats of reproductive age had higher vascular responsiveness in the normal condition and a lower decrease in vascular responsiveness after traumatic shock than older men and male rats of identical age. Exogenous supplementation of 17 beta-estrdiol increased vascular reactivity in both male and femal rats of 8-24 wk and preserved vascular responsiveness in rats following traumatic shock. No effect was observed in rats 1 to 1.5 years. These protective effects of estrogen were closely related to G protein-coupled receptor (GPR) 30, estrogen receptor-mediated Rho kinase, and PKC pathway activation. Vascular responsiveness exhibits age-and sex-based differences in healthy subjects and trauma patients. Estrogen and its receptor (GPR30) mediated activation of Rho kinase and PKC using genomic and nongenomic mechanisms to elicit protective effects in vascular responsiveness. This finding is important for the personalized treatment for several age-and sex-related diseases involving estrogen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据