期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 300, 期 4, 页码 H1545-H1555出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00867.2010
关键词
cardiac function; perfusion; ventilation
资金
- National Science Council of Taiwan [NSC 96-2314-B-182-001]
- Chang Gung University [CMRPG 280241]
Fu TC, Wang CH, Hsu CC, Cherng WJ, Huang SC, Wang JS. Suppression of cerebral hemodynamics is associated with reduced functional capacity in patients with heart failure. Am J Physiol Heart Circ Physiol 300: H1545-H1555, 2011. First published January 28, 2011; doi:10.1152/ajpheart.00867.2010.-This investigation elucidated the underlying mechanisms of functional impairments in patients with heart failure (HF) by simultaneously comparing cardiac-cerebral-muscle hemodynamic and ventilatory responses to exercise among HF patients with various functional capacities. One hundred one patients with HF [New York Heart Association HF functional class II (HF-II, n = 53) and functional class III (HF-III, n = 48) patients] and 71 normal subjects [older control (O-C, n = 39) and younger control (Y-C, n = 32) adults] performed an incremental exercise test using a bicycle ergometer. A recently developed noninvasive bioreactance device was adopted to measure cardiac hemodynamics, and near-infrared spectroscopy was employed to assess perfusions in the frontal cerebral lobe (Delta[THb](FC)) and vastus lateralis muscle (Delta[THb](VL)). The results demonstrated that the Y-C group had higher levels of cardiac output, Delta[THb](FC), and Delta[THb](VL) during exercise than the O-C group. Moreover, these cardiac/peripheral hemodynamic responses to exercise in HF-III group were smaller than those in both HF-II and O-C groups. Although the change of cardiac output caused by exercise was normalized, the amounts of blood distributed to frontal cerebral lobe and vastus lateralis muscle in the HF-III group significantly declined during exercise. The HF-III patients had lower oxygen-uptake efficiency slopes (OUES) and greater (V) over dot(E)-(V) over dot(O2) slopes than the HF-II patients and age-matched controls. However, neither hemodynamic nor ventilatory response to exercise differed significantly between the HF-II and O-C groups. Cardiac output, Delta[THb](FC), and Delta[THb](VL) during exercise were directly related to the OUES and (V) over dot O(2)peak and inversely related to the (V) over dot(E)-(V) over dot(CO2) slope. Moreover, cardiac output or Delta[THb](FC) was an effect modifier, which modulated the correlation status between Delta[THb](VL) and (V) over dot(E)-(V) over dot(CO2) slope. We concluded that the suppression of cerebral/ muscle hemodynamics during exercise is associated with ventilatory abnormality, which reduces functional capacity in patients with HF.
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