期刊
NATURE REVIEWS CANCER
卷 8, 期 5, 页码 361-375出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2374
关键词
-
类别
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000C197, BBS/E/B/0000C199, BBS/E/B/0000C116, C20001, BBS/E/B/00001116] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000C199, BBS/E/B/0000C116, BBS/E/B/00001116, C20001, BBS/E/B/0000C197] Funding Source: Medline
- British Heart Foundation Funding Source: Medline
Increases in cytosolic free Ca2+ ([Ca2+](i)) represent a ubiquitous signalling mechanism that controls a variety of cellular processes, including proliferation, metabolism and gene transcription, yet under certain conditions increases in intracellular Ca2+ are cytotoxic. Thus, in using Ca2+ as a messenger, cells walk a tightrope in which [Ca2+](i) is strictly maintained within defined boundaries. To adhere to these boundaries and to sustain their modified phenotype, many cancer cells remodel the expression or activity of their Ca2+ signalling apparatus. Here, we review the role of Ca2+ in promoting cell proliferation and cell death, how these processes are remodelled in cancer and the opportunities this might provide for therapeutic intervention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据