期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 304, 期 5, 页码 G449-G468出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00199.2012
关键词
fibrosis; autoimmune hepatitis; PBC; PSC; HCV; HBV; NASH; ALD
资金
- Marie Curie Initial Training Network (ITN) IT-Liver grant
- Netherlands Organization for Scientific Research (NWO)
- Netherlands Institute for Regenerative Medicine (NIRM)
- Netherlands Centre for Biomedical Genetics
- National Natural Science Foundation of China [81100278]
- Zhejiang Provincial Natural Science Foundation of China [Y2110026]
- German Research Foundation programs [SFB TRR77, Do373/8-1]
- Federal Ministry of Education and Research grants
Liu Y, Meyer C, Xu C, Weng H, Hellerbrand C, ten Dijke P, Dooley S. Animal models of chronic liver diseases. Am J Physiol Gastrointest Liver Physiol 304: G449-G468, 2013. First published December 28, 2012; doi:10.1152/ajpgi.00199.2012.-Chronic liver diseases are frequent and potentially life threatening for humans. The underlying etiologies are diverse, ranging from viral infections, autoimmune disorders, and intoxications (including alcohol abuse) to imbalanced diets. Although at early stages of disease the liver regenerates in the absence of the insult, advanced stages cannot be healed and may require organ transplantation. A better understanding of underlying mechanisms is mandatory for the design of new drugs to be used in clinic. Therefore, rodent models are being developed to mimic human liver disease. However, no model to date can completely recapitulate the corresponding human disorder. Limiting factors are the time frame required in humans to establish a certain liver disease and the fact that rodents possess a distinct immune system compared with humans and have different metabolic rates affecting liver homeostasis. These features account for the difficulties in developing adequate rodent models for studying disease progression and for testing new pharmaceuticals to be translated into the clinic. Nevertheless, traditional and new promising animal models that mimic certain attributes of chronic liver diseases are established and being used to deepen our understanding in the underlying mechanisms of distinct liver diseases. This review aims at providing a comprehensive overview of recent advances in animal models recapitulating different features and etiologies of human liver diseases.
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