期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 301, 期 3, 页码 G425-G434出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00050.2011
关键词
extracellular matrix; hepatic stellate cell/myofibroblast; inflammation; antifibrotic therapy
Integrins and other cell adhesion molecules regulate numerous physiological and pathological mechanisms by mediating the interaction between cells and their extracellular environment. Although the significance of integrins in the evolution and progression of certain cancers is well recognized, their involvement in nonmalignant processes, such as organ fibrosis or inflammation, is only beginning to emerge. However, accumulating evidence points to an instrumental role of integrin-mediated signaling in a variety of chronic and acute noncancerous diseases, particularly of the liver.
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