期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 294, 期 4, 页码 G850-G854出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00523.2007
关键词
ischemia-reperfusion; endocannabinoids; cannabinoid 2 receptor; inflammation; endothelium
资金
- Intramural NIH HHS [Z99 AA999999, Z01 AA000375-02] Funding Source: Medline
Recent studies have implicated dysregulation of the endocannabinoid system in various liver diseases and their complications ( e. g., hepatitis, fibrosis, cirrhosis, cirrhotic cardiomyopathy, and ischemia-reperfusion), and demonstrated that its modulation by either cannabinoid 2 (CB2) receptor agonists or CB1 antagonists may be of significant therapeutic benefits. This review is aimed to focus on the triggers and sources of endocannabinoids during liver inflammation and on the novel role of CB2 receptors in the interplay between the activated endothelium and various inflammatory cells ( leukocytes, lymphocytes, etc.), which play pivotal role in the early development and progression of inflammatory and other liver diseases.
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