期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 298, 期 2, 页码 E141-E145出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00712.2009
关键词
glucose transporter proteins; myoinositol transporters; urate transporters
资金
- National Institutes of Health [R0143695]
- Swiss National Science Foundation [31003A-113525]
- Juvenile Diabetes Research Foudation [7-2005-1158]
- European Community [LSHM-CT2006 518153]
Thorens B, Mueckler M. Glucose transporters in the 21st Century. Am J Physiol Endocrinol Metab 298: E141-E145, 2010. First published December 15, 2009; doi:10.1152/ajpendo.00712.2009.-The ability to take up and metabolize glucose at the cellular level is a property shared by the vast majority of existing organisms. Most mammalian cells import glucose by a process of facilitative diffusion mediated by members of the Glut (SLC2A) family of membrane transport proteins. Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. The primary physiological substrates for at least half of the 14 Glut proteins are either uncertain or unknown. The well-established glucose transporter isoforms, Gluts 1-4, are known to have distinct regulatory and/or kinetic properties that reflect their specific roles in cellular and whole body glucose homeostasis. Separate review articles on many of the Glut proteins have recently appeared in this journal. Here, we provide a very brief summary of the known properties of the 14 Glut proteins and suggest some avenues of future investigation in this area.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据