期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 298, 期 4, 页码 E742-E750出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00541.2009
关键词
ErbB receptors; exercise; glucose transport; insulin; mitochondrial biogenesis
资金
- Ministry of Science and Innovation [SAF2008-01723, SAF2008-03803]
- Instituto de Salud Carlos III [2009SGR915]
Guma A, Martinez-Redondo V, Lopez-Soldado I, Canto C, Zorzano A. Emerging role of neuregulin as a modulator of muscle metabolism. Am J Physiol Endocrinol Metab 298: E742-E750, 2010. First published December 22, 2009; doi:10.1152/ajpendo.00541.2009.-Neuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness.
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