期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 296, 期 1, 页码 E11-E21出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.90563.2008
关键词
insulin; mice; rat; dog; glycogen; epinephrine; hexokinase; glucose transport; glucose delivery
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [R01-DK-50277, R01-DK-54902, U24-DK-59637, P60-DK-20593]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [U24DK059637, R01DK050277, P60DK020593, R01DK054902] Funding Source: NIH RePORTER
Wasserman DH. Four grams of glucose. Am J Physiol Endocrinol Metab 295: E11-E21, 2008. First published October 7, 2008; doi: 10.1152/ajpendo.90563.2008.-Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is critical for normal function in many cell types. In accordance with the importance of these 4 g of glucose, a sophisticated control system is in place to maintain blood glucose constant. Our focus has been on the mechanisms by which the flux of glucose from liver to blood and from blood to skeletal muscle is regulated. The body has a remarkable capacity to satisfy the nutritional need for glucose, while still maintaining blood glucose homeostasis. The essential role of glucagon and insulin and the importance of distributed control of glucose fluxes are highlighted in this review. With regard to the latter, studies are presented that show how regulation of muscle glucose uptake is regulated by glucose delivery to muscle, glucose transport into muscle, and glucose phosphorylation within muscle.
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