相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The regulation and function of Class III PI3Ks: novel roles for Vps34
Jonathan M. Backer
BIOCHEMICAL JOURNAL (2008)
Amino acids activate mTOR Complex 1 via Ca2+/CaM signaling to hVps34
Pawan Gulati et al.
CELL METABOLISM (2008)
Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis
Micah J. Drummond et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Valeria Facchinetti et al.
EMBO JOURNAL (2008)
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
Maurice Phillip DeYoung et al.
GENES & DEVELOPMENT (2008)
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
Gabor Juhasz et al.
JOURNAL OF CELL BIOLOGY (2008)
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
Daniela Cota et al.
JOURNAL OF NEUROSCIENCE (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Nutrient sensing: TOR's ragtime
Alfred J. Meijer et al.
NATURE CELL BIOLOGY (2008)
Leucine and Protein Synthesis: mTOR and Beyond
Martha H. Stipanuk
NUTRITION REVIEWS (2008)
Phospholipase D1 is an effector of Rheb in the mTOR pathway
Y. Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38
Frank Edlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
Xiaochun Bai et al.
SCIENCE (2007)
Suppression of viral replication by stress-inducible GADD34 protein via the mammalian Serine/Threonine protein kinase mTOR pathway
Kahori Minami et al.
JOURNAL OF VIROLOGY (2007)
Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae
Sara A. Zurita-Martinez et al.
GENETICS (2007)
The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells
Paul-Joseph Aspuria et al.
CELL CYCLE (2007)
The rheb switch 2 segment is critical for signaling to target of rapamycin complex 1
Xiaomeng Long et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90
Frank Edlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
Dayna J. Hall et al.
BMC BIOLOGY (2007)
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
Ya-Chieh Hsu et al.
NATURE (2007)
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
Greg M. Findlay et al.
BIOCHEMICAL JOURNAL (2007)
The molecular bases of training adaptation
Vernon G. Coffey et al.
SPORTS MEDICINE (2007)
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1
Hongmei Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A role for phospholipase D in Drosophila embryonic cellularization
Mary LaLonde et al.
BMC DEVELOPMENTAL BIOLOGY (2006)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
The tuberous sclerosis complex
Peter B. Crino et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
Ken Inoki et al.
CELL (2006)
Leucine in food mediates some of the postprandial rise in plasma leptin concentrations
Christopher J. Lynch et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes
Chong-Shan Shi et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Amino acids regulate retrieval of the yeast general amino acid permease from the vacuolar targeting pathway
Marta Rubio-Texeira et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast
Minggeng Gao et al.
NATURE CELL BIOLOGY (2006)
Hypothalamic mTOR signaling regulates food intake
D Cota et al.
SCIENCE (2006)
Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p
BQ Wu et al.
JOURNAL OF CELL BIOLOGY (2006)
Cell hydration and mTOR-dependent signalling
F. Schliess et al.
ACTA PHYSIOLOGICA (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
Regulation of membrane traffic by phosphoinositide 3-kinases
K Lindmo et al.
JOURNAL OF CELL SCIENCE (2006)
Regulation of the small GTPase Rheb by amino acids
M Roccio et al.
ONCOGENE (2006)
Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast
J Urano et al.
MOLECULAR MICROBIOLOGY (2005)
Saccharomyces cerevisiae GTPase complex:: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p
YG Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways
DJ Kwiatkowski et al.
HUMAN MOLECULAR GENETICS (2005)
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase
T Nobukuni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
MP Byfield et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Association of the GTP-binding protein Gtr1p with Rpc19p, a shared subunit of RNA polymerase I and III in yeast Saccharomyces cerevisiae
Y Todaka et al.
GENETICS (2005)
Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin
F Edlich et al.
EMBO JOURNAL (2005)
Regulation of mTOR and cell growth in response to energy stress by REDD1
A Sofer et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The TOR and EGO protein complexes orchestrate microautophagy in yeast
F Dubouloz et al.
MOLECULAR CELL (2005)
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
XM Long et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
SM Ali et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
EM Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Rheb binds and regulates the mTOR kinase
X Long et al.
CURRENT BIOLOGY (2005)
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
AC Maurin et al.
CELL METABOLISM (2005)
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
SZ Hao et al.
SCIENCE (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Translational regulation of GCN4 and the general amino acid control of yeast
AG Hinnebusch
ANNUAL REVIEW OF MICROBIOLOGY (2005)
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki et al.
NATURE GENETICS (2005)
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
N Oshiro et al.
GENES TO CELLS (2004)
Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes
T Kanazawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D
T Sekiguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2
TG Anthony et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1
YM Fang et al.
CURRENT BIOLOGY (2003)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Drosophila Rheb GTPase is required for cell cycle progression and cell growth
PH Patel et al.
JOURNAL OF CELL SCIENCE (2003)
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
AF Castro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
CURRENT BIOLOGY (2003)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38
M Rosner et al.
ONCOGENE (2003)
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Y Zhang et al.
NATURE CELL BIOLOGY (2003)
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
H Stocker et al.
NATURE CELL BIOLOGY (2003)
Rheb promotes cell growth as a component of the insulin/TOR signalling network
LJ Saucedo et al.
NATURE CELL BIOLOGY (2003)
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
A Garami et al.
MOLECULAR CELL (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schaim et al.
CURRENT BIOLOGY (2003)
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
H Nojima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes
C Roh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomyces cerevisiae
EJ Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
TOR deficiency in C-elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
XM Long et al.
CURRENT BIOLOGY (2002)
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
R Loewith et al.
MOLECULAR CELL (2002)
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes
U Krause et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
DC Fingar et al.
GENES & DEVELOPMENT (2002)
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
JL Crespo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Identification of a conserved motif required for mTOR signaling
SS Schalm et al.
CURRENT BIOLOGY (2002)
Membrane transport in Caenorhabditis elegans:: an essential role for VPS34 at the nuclear membrane
L Roggo et al.
EMBO JOURNAL (2002)
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner
GR Christie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
YM Fang et al.
SCIENCE (2001)
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
I Novoa et al.
JOURNAL OF CELL BIOLOGY (2001)
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
T Sekiguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
ME Pacold et al.
CELL (2000)
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
HB Zhang et al.
GENES & DEVELOPMENT (2000)
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
S Oldham et al.
GENES & DEVELOPMENT (2000)
Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway
S Mordier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Formation of the Ras dimer is essential for Raf-1 activation
K Inouye et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
